(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester
CAS No.:852620-22-5
Molecular Formula:C₃₆H₄₃NO₆
Molecular Weight:585.741
Hs Code.:

(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

Synonyms:(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

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Chemical Property of (2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

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Technology Process of (2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

There total 6 articles about (2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 852620-21-4
Allyl-((2S,3S,4R,5R,6R)-2-allyl-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester

: 852620-22-5
(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; for 6h; Heating;
DOI:10.1002/anie.200462413

Reference yield:

: (2S,4R,5R,6R)-2-Allyl-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-ylamine

: 852620-22-5
(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 3 h / 20 °C

2: 98 percent / NaH / dimethylformamide / 1 h / 0 °C

3: 94 percent / bis(tricyclohexylphosphino)(benzylidene)ruthenium dichloride / CH₂Cl₂ / 6 h / Heating

With Grubbs catalyst first generation; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200462413

Reference yield:

: 852620-19-0
(2S,3S,4R,5R,6R)-2-Allyl-4,5-bis-benzyloxy-6-benzyloxymethyl-3-nitro-tetrahydro-pyran

: 852620-22-5
(2R,3R,4R,4aS,9aS)-3,4-Bis-benzyloxy-2-benzyloxymethyl-3,4,4a,6,9,9a-hexahydro-2H-1-oxa-5-aza-benzocycloheptene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 0 - 20 °C

2: Et₃N / CH₂Cl₂ / 3 h / 20 °C

3: 98 percent / NaH / dimethylformamide / 1 h / 0 °C

4: 94 percent / bis(tricyclohexylphosphino)(benzylidene)ruthenium dichloride / CH₂Cl₂ / 6 h / Heating

With lithium aluminium tetrahydride; Grubbs catalyst first generation; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200462413