N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Base Information

Chemical Name:N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide
CAS No.:1416953-12-2
Molecular Formula:C₂₄H₂₂N₄O₆S₂
Molecular Weight:526.594
Hs Code.:

Synonyms:N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Technology Process of N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

There total 4 articles about N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1416953-05-3
N-(2,4-dimethoxybenzyl)-5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine

: 98-59-9
p-toluenesulfonyl chloride

: 1416953-12-2
N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;
DOI:10.1021/jo302324r

Reference yield:

: 1416952-98-1
C₁₇H₁₈N₄O₅S

: 1416953-12-2
N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; p-toluenesulfonyl chloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

With sodium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; mineral oil;
DOI:10.1021/jo302324r

Reference yield:

: 34966-97-7
1-(isothiocyanatomethyl)-2,4-dimethoxy benzene

: 1416953-12-2
N-(2,4-dimethoxybenzyl)-4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

With sodium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; mineral oil;
DOI:10.1021/jo302324r