benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

Base Information

Chemical Name:benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate
CAS No.:943740-00-9
Molecular Formula:C₄₄H₄₇N₅O₉
Molecular Weight:789.885
Hs Code.:

Synonyms:benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

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Chemical Property of benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

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Technology Process of benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

There total 5 articles about benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 943739-99-9
2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(3-(benzyloxy)-3-oxopropyl)phenyl)acetic acid

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 943740-00-9
benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield: 53.0%

: 943740-00-9
benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

Guidance literature:

Reference yield:

: 166316-48-9
4-(2-carboxyethyl)benzeneboronic acid

: 943740-00-9
benzyl 3-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2: 1,2-dichloro-ethane / 100 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide; dichloromethane / 20 °C

With 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00788