5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

Base Information

Chemical Name:5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole
CAS No.:1314593-60-6
Molecular Formula:C₂₁H₂₉NO
Molecular Weight:311.467
Hs Code.:

Synonyms:5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

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Technology Process of 5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

There total 7 articles about 5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1314593-59-3
2,4-dicyclopropyl-5-vinyl-1,3-oxazole

: 404934-09-4
4-tert-butylcyclohex-1-enyl nonaflate

: 1314593-60-6
5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; lithium chloride; In N,N-dimethyl-formamide; at 75 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201100382

Reference yield:

: 1173883-65-2
N-{(1E)-1-cyclopropyl-3-oxo-2-[2-(trimethylsilyl)ethoxy]but-1-en-1-yl}cyclopropanecarboxamide

: 1314593-60-6
5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 80 °C / Sealed tube; Inert atmosphere

2: sodium tetrahydroborate / ethanol / 20 °C / Inert atmosphere

3: iodine / 1,2-dichloro-ethane / 120 °C / Sealed tube; Inert atmosphere

4: palladium diacetate; triethylamine; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 3 h / 75 °C / Inert atmosphere

With sodium tetrahydroborate; iodine; palladium diacetate; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium chloride; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 4: Heck reaction;
DOI:10.1002/chem.201100382

Reference yield:

: C₁₂H₂₁NOSi

: 1314593-60-6
5-[(1E)-2-(4-tert-butyl-1-cyclohexenyl)vinyl]-2,4-dicyclopropyl-1,3-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether; hexane / -78 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / 80 °C / Sealed tube; Inert atmosphere

3: sodium tetrahydroborate / ethanol / 20 °C / Inert atmosphere

4: iodine / 1,2-dichloro-ethane / 120 °C / Sealed tube; Inert atmosphere

5: palladium diacetate; triethylamine; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 3 h / 75 °C / Inert atmosphere

With sodium tetrahydroborate; iodine; palladium diacetate; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium chloride; In diethyl ether; ethanol; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 5: Heck reaction;
DOI:10.1002/chem.201100382