trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole

Base Information

• Chemical Name: trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole
• CAS No.: 143998-57-6
• Molecular Formula: C₃₂H₃₄N₂O₂
• Molecular Weight: 478.634

Synonyms:trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole

Chemical Property of trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole

Chemical Property:

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Technology Process of trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole

There total 2 articles about trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

Methyl N-(diphenylmethylene)-D,L-tryptophanates (118553-32-5) + cyclohexanecarbaldehyde (2043-61-0) → trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole (143998-57-6)

Guidance literature:

With trifluoroacetic acid; In benzene; for 36h; Heating;

DOI:10.1021/jo951170a

Reference yield:

Methyl N-(diphenylmethylene)-D,L-tryptophanates (118553-32-5) → trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole (143998-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₃CN / methanol / 25 °C / pH = 6

2: TFA / benzene / 72 h / Heating

With sodium cyanoborohydride; trifluoroacetic acid; In methanol; benzene;

DOI:10.1016/S0040-4039(00)61268-6

Reference yield:

trans-1-cyclohexyl-3-(methoxycarbonyl)-2-(diphenylmethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole (143998-57-6) → trans-1-cyclohexyl-3-(methoxycarbonyl)-1-propyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole (73327-06-7)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 25 ℃;

DOI:10.1016/S0040-4039(00)61268-6

upstream raw materials:

Methyl N-(diphenylmethylene)-D,L-tryptophanates

cyclohexanecarbaldehyde

Downstream raw materials:

trans-1-cyclohexyl-3-(methoxycarbonyl)-1-propyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole

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