N,N'-Bis-tert-butoxycarbonylthiourea

Base Information

Chemical Name:N,N'-Bis-tert-butoxycarbonylthiourea
CAS No.:145013-05-4
Molecular Formula:C11H20N2O4S
Molecular Weight:276.357
Hs Code.:29302000
DSSTox Substance ID:DTXSID40409351
Nikkaji Number:J1.040.970E
Wikidata:Q72444396
Mol file:145013-05-4.mol

Synonyms:145013-05-4;N,N'-Bis-tert-butoxycarbonylthiourea;N,N'-Di-Boc-thiourea;BIS-BOC-THIOUREA;tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylcarbamothioyl]carbamate;n,n'-di(tert-butoxycarbonyl)thiourea;N,N'-bis(tert-butoxycarbonyl)thiourea;MFCD03093917;Thiodiimidotricarbonic acid ([(HO)C(O)NH]2C(S)), 1,5-bis(1,1-dimethylethyl) ester;DIBOC-THIOUREA;1,3-Bis(tert-butoxycarbonyl)thiourea;di-Boc-thiourea;bis boc thiourea;C11H20N2O4S;bis-N-Boc thiourea;N,N'-Di-(tert-butoxycarbonyl)thiourea;1,3-Di(Boc)thiourea;1,3-Di-Boc-thiourea;N,N`-Di-Boc-thiourea;Carbamic acid, carbonothioylbis-, bis(1,1-dimethylethyl) ester;N,N inverted exclamation marka-Di-Boc-thiourea;SCHEMBL151345;bis(tert-butoxycarbonyl)thiourea;N,N'-Di-Boc-thiourea, 97%;SCHEMBL16485735;DTXSID40409351;CSOJECDGWHHWRS-UHFFFAOYSA-N;2-bromo-3-4-dimethoxypropiophenone;AMY36756;N,N'-(tert-Butoxycarbonyl)thiourea;1,3-Di(tert-butoxycarbonyl)thiourea;1,3-Di-(tert-butoxycarbonyl)thiourea;1.3-Di-(tert-butoxycarbonyl)thiourea;AKOS015911976;N, N'-bis-tert-butoxycarbonylthiourea;CS-W014572;GS-3837;N, N'- bis-tert-butoxycarbonylthiourea;N,N'-Bis(tert-butoxycarbonyl) thiourea;N,N'-bis (tert-butoxycarbonyl )thiourea;BP-12428;SY017171;B4559;FT-0646914;A21826;N,N inverted exclamation mark -Di-Boc-thiourea;J-008038;tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate;2,2,10,10-tetramethyl-6-thioxo-3,9-dioxa-5,7-diazaundecane-4,8-dione;Thiodiimidotricarbonicacid([(ho)c(o)nh]2c(S)),1,5-bis(1,1-dimethylethyl)ester

Suppliers and Price of N,N'-Bis-tert-butoxycarbonylthiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N,N''-Di(tert-butoxycarbonyl)thiourea
5g
$ 450.00

TCI Chemical
1,3-Bis(tert-butoxycarbonyl)thiourea >98.0%(N)
5g
$ 650.00

TCI Chemical
1,3-Bis(tert-butoxycarbonyl)thiourea >98.0%(N)
1g
$ 157.00

Sigma-Aldrich
N,N′-Di-Boc-thiourea 97%
1g
$ 159.00

Sigma-Aldrich
N,N′-Di-Boc-thiourea 97%
5g
$ 522.00

Medical Isotopes, Inc.
N,N??-Di(tert-butoxycarbonyl)thiourea
5 g
$ 910.00

Matrix Scientific
N,N'-Bis-tert-butoxycarbonylthiourea 95+%
1g
$ 189.00

Matrix Scientific
N,N'-Bis-tert-butoxycarbonylthiourea 95+%
5g
$ 504.00

Crysdot
N,N'-Bis-tert-butoxycarbonylthiourea 95+%
100g
$ 772.00

Crysdot
N,N'-Bis-tert-butoxycarbonylthiourea 95+%
25g
$ 238.00

Total 50 raw suppliers

Chemical Property of N,N'-Bis-tert-butoxycarbonylthiourea

Chemical Property:

Melting Point:131-135 °C(lit.)
PKA:5.55±0.70(Predicted)
PSA：108.75000
Density:1.152 g/cm³
LogP:3.10250
Storage Temp.:Store at 0-5°C
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:276.11437830
Heavy Atom Count:18
Complexity:310

Purity/Quality:

97% ^*data from raw suppliers

N,N''-Di(tert-butoxycarbonyl)thiourea ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(=S)NC(=O)OC(C)(C)C
Uses N,N′-Di-Boc-thiourea (N,N′-di-Boc-substituted thiourea), also known as di-Boc-thiourea is a thioacylating agent for preparing thiocarbonyl compounds. N,N′-Di-Boc-thiourea (di-Boc protected thiourea) may be used as a guanylating agent for the synthesis of guanidines, via guanylation of amines in the presence of Mukaiyama′s reagent as a promoter. N,N''-Di(tert-butoxycarbonyl)thiourea is used in the preparation of bis-imidazoline diphenyl derivatives as α1-adrenoceptor antagonists.

Technology Process of N,N'-Bis-tert-butoxycarbonylthiourea

There total 4 articles about N,N'-Bis-tert-butoxycarbonylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 17356-08-0
thiourea

: 145013-05-4
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

Guidance literature:: thiourea; With sodium hydride; In tetrahydrofuran; n-heptane; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

di-tert-butyl dicarbonate; In tetrahydrofuran; n-heptane; at 0 ℃; for 3h;
DOI:10.1002/chem.201504520

Reference yield: 92.0%

: 34619-03-9
tert-butyldicarbonate

: 17356-08-0
thiourea

: 145013-05-4
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

Guidance literature:: thiourea; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

tert-butyldicarbonate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 3.66667h; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.077