ATH 686

Base Information

Chemical Name:ATH 686
CAS No.:853299-52-2
Molecular Formula:C₂₅H₂₈F₃N₇O₂
Molecular Weight:515.538
Hs Code.:

Synonyms:1-[4-(2-aminopyrimidin-4-yloxy)phenyl]-3-[4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea

Suppliers and Price of ATH 686

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
ATH686 >98%
1 g
$ 2600.00

Total 4 raw suppliers

Chemical Property of ATH 686

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

ATH686 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ATH 686

There total 12 articles about ATH 686 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4-(4-aminophenoxy)pyrimidin-2-ylamine dihydrochloride salt

: [4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenyl]carbamic acid phenyl ester hydrochloride

: 853299-52-2
1-[4-(2-aminopyrimidin-4-yloxy)phenyl]-3-[4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 65 ℃; for 2h; Large scale;
DOI:10.1021/op800136f

Reference yield: 38.0%

: 630125-91-6
4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenylamine

: 417724-26-6
4-(4-amino-phenoxy)-pyrimidin-2-ylamine

: 853299-52-2
1-[4-(2-aminopyrimidin-4-yloxy)phenyl]-3-[4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea

Guidance literature:: With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/op800136f

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 853299-52-2
1-[4-(2-aminopyrimidin-4-yloxy)phenyl]-3-[4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.08 h / Inert atmosphere; Large scale

2.1: hydrogenchloride / toluene; ethyl acetate; water / 0.08 h / 20 - 25 °C / Large scale

2.2: 76 - 78 °C / Large scale

2.3: Large scale

3.1: triethylamine; bis(trichloromethyl) carbonate / dimethyl sulfoxide; dichloromethane

With hydrogenchloride; bis(trichloromethyl) carbonate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/op800136f