(R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

Base Information

Chemical Name:(R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane
CAS No.:195388-54-6
Molecular Formula:C₃₂H₃₀Cl₂OSi
Molecular Weight:529.581
Hs Code.:

Synonyms:(R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

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Technology Process of (R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

There total 7 articles about (R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (3,4-dichloro-phenyl)-trimethyl-stannane

: 195388-53-5
(R)-4-bromo-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene

: 195388-54-6
(R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

Guidance literature:: With 1-methyl-pyrrolidin-2-one; dichloro bis(acetonitrile) palladium(II); triphenyl-arsane; at 80 ℃; for 1.5h;
DOI:10.1021/jo971115x

Reference yield: 53.0%

: 151169-75-4
3,4-dichlophenylboronic acid

: 195388-53-5
(R)-4-bromo-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene

: 195388-54-6
(R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

Guidance literature:: With sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 60 ℃; for 3h;
DOI:10.1016/S0040-4020(99)00456-1

Reference yield:

: 123849-23-0
(R)-(+)-1-hydroxy-1,2-dihydronaphthalene

: 195388-54-6
(R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / imidazole; DMAP / CH₂Cl₂ / 3 h / 20 °C

2: Br₂; Et₃N / CH₂Cl₂

3: 510 mg / DBU / benzene / 20 °C

4: 55 percent / (MeCN)2PdCl₂; AsPh₃ / 1-methyl-pyrrolidin-2-one / 1.5 h / 80 °C

With 1H-imidazole; dmap; bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dichloro bis(acetonitrile) palladium(II); triphenyl-arsane; In 1-methyl-pyrrolidin-2-one; dichloromethane; benzene; 1: Substitution / 2: Bromination / 3: Dehydrobromination / 4: Arylation;
DOI:10.1016/S0040-4020(99)00456-1