2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide

Base Information

• Chemical Name: 2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide
• CAS No.: 1092547-05-1
• Molecular Formula: C₂₀H₁₆F₃N₃OS
• Molecular Weight: 403.428

Synonyms:2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide

Chemical Property of 2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide

Chemical Property:

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Technology Process of 2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide

There total 2 articles about 2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-bromo-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide (1092546-92-3) + aniline (62-53-3) → 2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide (1092547-05-1) + N-[4-(methylthio)phenyl]-6-phenyl-2-(phenylamino)-4-(trifluoromethyl)nicotinamide (1092547-15-3)

Guidance literature:

With pyridine; for 72h; Reflux;

DOI:10.1248/cpb.56.1342

Reference yield: 69.0%

C13H9F3N2O2 + 4-methylsulfanylaniline (104-96-1) → 2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide (1092547-05-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1248/cpb.56.1342

Reference yield: 79.0%

2-amino-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide (1092547-05-1) + Triethyl orthopropionate (115-80-0) → 2-ethyl-3-[4-(methylthio)phenyl]-7-phenyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one (1092547-25-5)

Guidance literature:

With acetic acid; at 90 ℃; for 7h;

DOI:10.1248/cpb.56.1342

upstream raw materials:

2-bromo-N-[4-(methylthio)phenyl]-6-phenyl-4-(trifluoromethyl)nicotinamide

aniline

4-methylsulfanylaniline

Downstream raw materials:

2-ethyl-3-[4-(methylthio)phenyl]-7-phenyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one

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