9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

Base Information

Chemical Name:9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one
CAS No.:167645-16-1
Molecular Formula:C₁₇H₁₄FN₃OS
Molecular Weight:327.382
Hs Code.:

Synonyms:9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

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Chemical Property of 9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

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Technology Process of 9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

There total 8 articles about 9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 163155-65-5
Methanesulfonic acid 7-(2-fluoro-phenyl)-10-oxo-1,2,9,10-tetrahydro-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-9-yl ester

: 167645-16-1
9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

Guidance literature:: With ammonia; In dichloromethane; for 2h; Yield given; Ambient temperature;
DOI:10.1248/cpb.42.2071

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 167645-16-1
9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) BCl₃, AlCl₃, 2.) 2N aq. HCl / 1.) toluene, reflux, 16 h, 2.) toluene, reflux, 2.5 h

2: 68.9 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 26.5 percent / 50percent aq. NaOH, NH₂OH*HCl / ethanol / 2.5 h / 50 - 55 °C

4: CH₂Cl₂ / 6 h / 0 - 20 °C

5: aq. NaHCO₃ / ethanol / Ambient temperature

6: (iso-Pr)2NEt / CH₂Cl₂ / 1 h / Ambient temperature

7: methanol.NH₃ / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; ammonia; boron trichloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.2071

Reference yield:

: 3080-99-7
3,4-dihydro-2H-benzo[1,4]thiazine

: 167645-16-1
9-Amino-7-(2-fluoro-phenyl)-1,2-dihydro-9H-3-thia-8,10a-diaza-cyclohepta[de]naphthalen-10-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) BCl₃, AlCl₃, 2.) 2N aq. HCl / 1.) toluene, reflux, 16 h, 2.) toluene, reflux, 2.5 h

2: 68.9 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 26.5 percent / 50percent aq. NaOH, NH₂OH*HCl / ethanol / 2.5 h / 50 - 55 °C

4: CH₂Cl₂ / 6 h / 0 - 20 °C

5: aq. NaHCO₃ / ethanol / Ambient temperature

6: (iso-Pr)2NEt / CH₂Cl₂ / 1 h / Ambient temperature

7: methanol.NH₃ / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; ammonia; boron trichloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.2071