acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester

Base Information

• Chemical Name: acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester
• CAS No.: 464910-90-5
• Molecular Formula: C₁₅H₂₂O₂Si
• Molecular Weight: 262.424
• Mol file: 464910-90-5.mol

Synonyms:acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester

Chemical Property of acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester

Chemical Property:

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Technology Process of acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester

There total 1 articles about acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-methylbut-2-enal (497-03-0) + acetic anhydride (108-24-7) + C16H22CuSi2(1+)*2I(1-)*Li(1+) → acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester (464910-90-5)

Guidance literature:

2-methylbut-2-enal; C₁₆H₂₂CuSi₂⁽¹⁺⁾*2I^(1-)*Li⁽¹⁺⁾; at -78 - -30 ℃; for 3h;

acetic anhydride; at -30 - 23 ℃; for 12h; Further stages.;

DOI:10.1021/ol026343e

Reference yield: 90.0%

(R)-2-oxopropionic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester (464911-23-7) + acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester (464910-90-5) → Acetic acid (E)-(S)-3-(dimethyl-phenyl-silanyl)-2-methyl-but-1-enyl ester + (2R,3S,4S,5S)-3-acetoxy-4-dimethylphenylsilyl-2,4,5-trimethyltetrahydrofuran-2-carboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -78 ℃; for 24h;

DOI:10.1021/ol026343e

Reference yield: 85.0%

2-oxo-propionic acid ethyl ester (617-35-6) + acetic acid 2-methyl-3-(dimethylphenylsilyl)-(E)-but-1-enyl ester (464910-90-5) → (2R*,3S*,4S*,5S*)-3-acetoxy-4-dimethylphenylsilyl-2,4,5-trimethyltetrahydrofuran-2-carboxylic acid ethyl ester

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1021/ol026343e

upstream raw materials:

2-methylbut-2-enal

acetic anhydride