2-fluoro-5-aminobenzaldehyde dimethyl acetal

Base Information

Chemical Name:2-fluoro-5-aminobenzaldehyde dimethyl acetal
CAS No.:103438-83-1
Molecular Formula:C₉H₁₂FNO₂
Molecular Weight:185.198
Hs Code.:

Synonyms:2-fluoro-5-aminobenzaldehyde dimethyl acetal

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Chemical Property of 2-fluoro-5-aminobenzaldehyde dimethyl acetal

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Technology Process of 2-fluoro-5-aminobenzaldehyde dimethyl acetal

There total 1 articles about 2-fluoro-5-aminobenzaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2-(dimethoxymethyl)-1-fluoro-4-nitrobenzene

: 103438-83-1
2-fluoro-5-aminobenzaldehyde dimethyl acetal

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.1021/acs.jmedchem.0c00508

Reference yield: 87.0%

: 1417403-99-6
8-chloro-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-3-carboxylic acid 2-(morpholin-4-yl)ethyl amide

: 103438-83-1
2-fluoro-5-aminobenzaldehyde dimethyl acetal

: 8-((3-(dimethoxymethyl)-4-fluorophenyl)amino)-N-(2-morpholinoethyl)-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxamide

Guidance literature:: With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate; potassium carbonate; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.jmedchem.0c00508

Reference yield:

: 103438-83-1
2-fluoro-5-aminobenzaldehyde dimethyl acetal

: 103439-07-2
6-fluorophenylephrine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium nitrite, H₂SO₄, 2.) Cu(NO₃)2, Cu₂O / 1.) H₂O, 0-5 deg C, 5 min, 2.) H₂O

2: 76 percent / K₂CO₃ / acetone / Ambient temperature

3: 1.) ZnI₂, 2.) LiAlH₄ / 1.) overnight, 2.) ether, reflux, 3 h

4: 72 percent / 6 h / Heating

5: 81 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

6: H₂ / Pd/C / ethanol / 1034.3 Torr

With copper(I) oxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; potassium carbonate; copper(II) nitrate; zinc(II) iodide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm00160a030