2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

Base Information

Chemical Name:2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole
CAS No.:1345041-92-0
Molecular Formula:C₁₈H₁₅ClN₄S₂
Molecular Weight:386.929
Hs Code.:

Synonyms:2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

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Chemical Property of 2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

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Technology Process of 2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

There total 11 articles about 2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₇ClN₄OS₂

: 1345041-92-0
2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 6h; Reflux;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 1000400-63-4
potassium 4-(4-chlorophenyl)-2-oxobut-3-enoate

: 1345041-92-0
2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 °C / Reflux

2.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

2.2: 10 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 4 h / Reflux

4.1: potassium hydroxide / methanol / 2.5 h / 0 - 20 °C

5.1: methanol / 25 - 30 °C

6.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

With thionyl chloride; toluene-4-sulfonic acid; hydrazine hydrate; potassium hydroxide; In methanol; ethanol; toluene;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-92-0
2-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-5-(methylthio)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 4 h / Reflux

3.1: potassium hydroxide / methanol / 2.5 h / 0 - 20 °C

4.1: methanol / 25 - 30 °C

5.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; potassium hydroxide; In methanol; ethanol; toluene;
DOI:10.1016/j.bmcl.2011.08.061