6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Base Information

Chemical Name:6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
CAS No.:1352128-48-3
Molecular Formula:C₁₇H₁₆BrN₃O₃S₂
Molecular Weight:454.368
Hs Code.:

Synonyms:6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

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Chemical Property of 6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

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Technology Process of 6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

There total 6 articles about 6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 23121-10-0
1-chloromethyl-2-ethanesulfonyl-benzene

: 352328-87-1
6-bromo-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352128-48-3
6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: 6-bromo-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one; With sodium hydride; lithium bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.5h;

1-chloromethyl-2-ethanesulfonyl-benzene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h;

Reference yield:

: 4892-02-8
Methyl thiosalicylate

: 1352128-48-3
6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 1 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 4 h / Reflux

4.1: Oxone / water; methanol / 18 h / 20 °C

5.1: sodium hydride; lithium bromide / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

5.2: 18 h / 20 °C

With Oxone; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; potassium carbonate; lithium bromide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 211244-81-4
2-methanesulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352128-48-3
6-bromo-8-(2-ethanesulfonyl-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydride; lithium bromide / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

2.2: 18 h / 20 °C

With N-Bromosuccinimide; sodium hydride; lithium bromide; In N,N-dimethyl-formamide; mineral oil;