C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin

Base Information

• Chemical Name: C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin
• CAS No.: 284676-81-9
• Molecular Formula: C₅₉H₈₈BrNO₁₃Si
• Molecular Weight: 1127.34
• Mol file: 284676-81-9.mol

Synonyms:C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin

Chemical Property of C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin

There total 1 articles about C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

(o-bromophenyl)dimethylsilyl chloride (130350-97-9) + sirolimus (53123-88-9) → C(40)-O-(ortho-bromophenyldimethylsilyl)-rapamycin (284676-81-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at -10 - 10 ℃;

DOI:10.1002/(SICI)1099-1344(200002)43:2<113::AID-JLCR295>3.0.CO;2-C

Reference yield:

2-{[tert-butyl(diphenyl)silyl]oxy}ethyl trifluoromethansulphonate (1314705-19-5) + C(40)-O-(ortho-bromophenyldimethylsilyl)-rapamycin (284676-81-9) → C69H100(3)HNO14Si + C69H100(3)HNO14Si + C69H100(3)HNO14Si + C69H100(3)HNO14Si

Guidance literature:

C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin; With tri-n-butyltin tritiide; triethyl borane; In tetrahydrofuran; at 23 ℃; for 2h;

With acetic acid; In tetrahydrofuran; at 0 ℃; for 2.5h;

2-{[tert-butyl(diphenyl)silyl]oxy}ethyl trifluoromethansulphonate; With N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; toluene; at 50 ℃; for 3h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1002/(SICI)1099-1344(200002)43:2<113::AID-JLCR295>3.0.CO;2-C

Reference yield:

2-{[tert-butyl(diphenyl)silyl]oxy}ethyl trifluoromethansulphonate (1314705-19-5) + C(40)-O-(ortho-bromophenyldimethylsilyl)-rapamycin (284676-81-9) → C53H82(3)HNO14 + C53H82(3)HNO14 + C53H82(3)HNO14 + C53H82(3)HNO14

Guidance literature:

Multistep reaction. Further byproducts given. Title compound not separated from byproducts;

DOI:10.1002/(SICI)1099-1344(200002)43:2<113::AID-JLCR295>3.0.CO;2-C

upstream raw materials:

(o-bromophenyl)dimethylsilyl chloride

sirolimus