(S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol

Base Information

• Chemical Name: (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol
• CAS No.: 121612-73-5
• Molecular Formula: C₁₇H₁₆N₂O₂S
• Molecular Weight: 312.392
• Mol file: 121612-73-5.mol

Synonyms:(S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol

Chemical Property of (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol

There total 3 articles about (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

L-Phenylalaninol (3182-95-4) + Thieno[2,3-b]pyridine-5-carbonyl chloride (121612-70-2) → (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol (121612-73-5)

Guidance literature:

With triethylamine; In dichloromethane; 1) -20 deg C, 1 h, 2) room temperature, 24 h;

Reference yield:

thieno<2,3-b>pyridine-5-carboxylic acid (117390-38-2) → (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol (121612-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 12 h / Heating

2: 73 percent / Et₃N / CH₂Cl₂ / 1) -20 deg C, 1 h, 2) room temperature, 24 h

With thionyl chloride; triethylamine; In dichloromethane;

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (S)-(-)-N-(thieno<2,3-b>pyridine-5-carbonyl)phenylalaninol (121612-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: 73 percent / Et₃N / CH₂Cl₂ / 1) -20 deg C, 1 h, 2) room temperature, 24 h

With lithium aluminium tetrahydride; triethylamine; In dichloromethane;

upstream raw materials:

L-Phenylalaninol

Thieno[2,3-b]pyridine-5-carbonyl chloride

thieno<2,3-b>pyridine-5-carboxylic acid

L-phenylalanine

Downstream raw materials:

(RS)-methyl mandelate

5-((S)-1-Hydroxymethyl-2-phenyl-ethylcarbamoyl)-7-methyl-thieno[2,3-b]pyridin-7-ium; iodide

(S)-N-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonyl)phenylalaninol