(S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

Base Information

Chemical Name:(S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid
CAS No.:79974-21-3
Molecular Formula:C₁₅H₁₉N₃O₆
Molecular Weight:337.332
Hs Code.:

Synonyms:(S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

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Chemical Property of (S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

Chemical Property:

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Technology Process of (S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

There total 7 articles about (S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79974-11-1
(S)-4-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-(benzyloxycarbonylmethyl-carbamoyl)-butyric acid benzyl ester

: 79974-21-3
(S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 20h; Ambient temperature;
DOI:10.1021/jm00344a018

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 79974-21-3
(S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / (i-Pr)2NEt / dioxane; H₂O

2: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

3: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

4: H₂ / 5percent Pd/C / dioxane / 20 h / Ambient temperature

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00344a018

Reference yield:

: 10541-83-0,937737-33-2
N-methyl-p-aminobenzoic acid

: 79974-21-3
(S)-4-(Carboxymethyl-carbamoyl)-4-(4-methylamino-benzoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / 2 N NaOH / dioxane; H₂O / 0.5 h / 0 - 5 °C

2: 99 percent / SOCl₂ / benzene / 2 h / Heating

3: 68 percent / (i-Pr)2NEt / dioxane; H₂O

4: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

5: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

6: H₂ / 5percent Pd/C / dioxane / 20 h / Ambient temperature

With sodium hydroxide; thionyl chloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00344a018