4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester

Base Information

• Chemical Name: 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester
• CAS No.: 2379-15-9
• Molecular Formula: C₂₄H₂₈I₂O₆
• Molecular Weight: 666.292
• Mol file: 2379-15-9.mol

Synonyms:4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester

Chemical Property of 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester

There total 5 articles about 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<4-Benzoyloxy-3-tert.-butyl-phenyl>-benzyl-aether (2444-23-7) → 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester (2379-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd-C / ethanol

2: (i) (nitration), (ii) /BRN= 2655601/, MeSO₂Cl

3: (i) (catalytic hydrogenation), (ii) NaNO₂, H₂SO₄, (iii) aq. NaI, I₂, CHCl₃, urea

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00328a012

Reference yield:

tert-butylhydroquinone (1948-33-0) → 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester (2379-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) aq. NaOH, EtOH, (ii) /BRN= 471389/, Py

2: H₂ / Pd-C / ethanol

3: (i) (nitration), (ii) /BRN= 2655601/, MeSO₂Cl

4: (i) (catalytic hydrogenation), (ii) NaNO₂, H₂SO₄, (iii) aq. NaI, I₂, CHCl₃, urea

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00328a012

Reference yield:

4-<3-tert.Butyl-4-hydroxy-phenoxy>-3.5-dinitro-benzylidenmalonsaeure-diaethylester (2621-54-7) → 4-<3-tert.-Butyl-4-hydroxy-phenoxy>-3,5-diiod-benzylmalonsaeure-diethylester (2379-15-9)

Guidance literature:

Multistep reaction; (i) (catalytic hydrogenation), (ii) NaNO₂, H₂SO₄, (iii) aq. NaI, I₂, CHCl₃, urea;

DOI:10.1021/jm00328a012

upstream raw materials:

4-<3-tert.Butyl-4-hydroxy-phenoxy>-3.5-dinitro-benzylidenmalonsaeure-diaethylester

4-Benzoyloxy-3-tert.butyl-phenol

2-(4-hydroxybenzylidene)malonic acid diethyl ester

<4-Benzoyloxy-3-tert.-butyl-phenyl>-benzyl-aether

Downstream raw materials:

3-<4-(3-tert.Butyl-4-hydroxy-phenoxy)-3,5-diiod-phenyl>-propionsaeure