tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

Base Information

Chemical Name:tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate
CAS No.:151257-13-5
Molecular Formula:C₃₅H₄₇N₃O₅
Molecular Weight:589.775
Hs Code.:

Synonyms:tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

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Chemical Property of tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

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Technology Process of tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

There total 5 articles about tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 138401-29-3
tert-butyl 4'-<(2-n-butyl-4-oxo-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

: 151257-13-5
tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

Guidance literature:: With triethylamine; In toluene; for 18h;
DOI:10.1021/jm00074a018

Reference yield:

: 57611-55-9
4-amino-1-benzyl-4-ethoxycarbonylpiperidine

: 151257-13-5
tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: AcOH / xylene / 6.5 h / Heating

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 40 deg C, 3.5 h

3: 92 percent / H₂ / 10percent Pd/C / methanol / 18 h / 760 Torr

4: 64 percent / Et₃N / toluene / 18 h

With hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In methanol; toluene; xylene;
DOI:10.1021/jm00074a018

Reference yield:

: 138402-16-1
2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-4-one

: 151257-13-5
tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 40 deg C, 3.5 h

2: 92 percent / H₂ / 10percent Pd/C / methanol / 18 h / 760 Torr

3: 64 percent / Et₃N / toluene / 18 h

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jm00074a018