diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

Base Information

Chemical Name:diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate
CAS No.:1345984-08-8
Molecular Formula:C₃₁H₄₈N₃O₇PS
Molecular Weight:637.778
Hs Code.:

diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

Synonyms:diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

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Chemical Property of diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

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Technology Process of diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

There total 2 articles about diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 41468-36-4
diethyl (2-aminoethyl)phosphonate

: 1345983-54-1
N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-2-chloroacetamide

: 1345984-08-8
diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

Guidance literature:: diethyl (2-aminoethyl)phosphonate; N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-2-chloroacetamide; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

With potassium iodide; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 1345983-52-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine

: 1345984-08-8
diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 20 °C / Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2.2: 60 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 46.0%

: 1345984-08-8
diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate

: 76-05-1
trifluoroacetic acid

: 1345982-95-7
(2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonic acid trifluoroacetate

Guidance literature:: diethyl (2-{[2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)-2-oxoethyl]amino}ethyl)phosphonate; With trimethylsilyl bromide; In dichloromethane; at 20 ℃;

With hydrogenchloride; In water;

trifluoroacetic acid; In water; acetonitrile;