3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

Base Information

Chemical Name:3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol
CAS No.:941320-57-6
Molecular Formula:C₁₉H₃₂N₂O₂
Molecular Weight:320.475
Hs Code.:

Synonyms:3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

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Chemical Property of 3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

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Technology Process of 3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

There total 5 articles about 3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 941320-56-5
C₁₉H₃₀N₂O₂

: 941320-57-6
3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 3h;
DOI:10.1016/j.bmcl.2007.03.034

Reference yield:

: 5570-78-5
1-isopropylpiperidin-4-ol

: 941320-57-6
3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaH / dimethylformamide / 20 h / 120 °C

2: 31 percent / conc. HCl / ethanol / 24 h / 90 °C

3: 73 percent / sodium borohydride / ethanol / 3 h

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; In ethanol; N,N-dimethyl-formamide; 2: Mannich reaction;
DOI:10.1016/j.bmcl.2007.03.034

Reference yield:

: 941320-29-2
1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-ethanone

: 941320-57-6
3-dimethylamino-1-[4-(1-isopropyl-piperidin-4-yloxy)-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / conc. HCl / ethanol / 24 h / 90 °C

2: 73 percent / sodium borohydride / ethanol / 3 h

With hydrogenchloride; sodium tetrahydroborate; In ethanol; 1: Mannich reaction;
DOI:10.1016/j.bmcl.2007.03.034