5-Bromo-2-(chloromethyl)pyridine hydrochloride

Base Information

• Chemical Name: 5-Bromo-2-(chloromethyl)pyridine hydrochloride
• CAS No.: 936342-91-5
• Molecular Formula: C6H5BrClN.ClH
• Molecular Weight: 242.93
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10701213
• Mol file: 936342-91-5.mol

Synonyms:5-bromo-2-(chloromethyl)pyridine hydrochloride;936342-91-5;5-bromo-2-(chloromethyl)pyridine;hydrochloride;5-Bromo-2-chloromethyl-pyridine hydrochloride;SCHEMBL510328;DTXSID10701213;YDXPFHGVFYBITC-UHFFFAOYSA-N;MFCD09753756;AKOS016015011;DS-14216;5-bromo2-chloromethyl-pyridine hydrochloride;5-BROMO-2-(CHLOROMETHYL)PYRIDINE HCL;5-bromo-2-(chloromethyl)pyridinehydrochloride;EN300-75239;C77222;A859701;5-Bromo-2-(chloromethyl)pyridine--hydrogen chloride (1/1);5-Bromo-2-(chloromethyl)pyridine hydrochlorideMFCD09753756

Chemical Property of 5-Bromo-2-(chloromethyl)pyridine hydrochloride

Chemical Property:

• PSA: 12.89000
• LogP: 3.38490
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 240.90607
• Heavy Atom Count: 10
• Complexity: 89.1

Purity/Quality:

95% ^*data from raw suppliers

5-Bromo-2-(chloromethyl)pyridinehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1Br)CCl.Cl

Technology Process of 5-Bromo-2-(chloromethyl)pyridine hydrochloride

There total 3 articles about 5-Bromo-2-(chloromethyl)pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(5-bromopyridin-2-yl)methanol (88139-91-7) → 5-bromo-2-chloromethylpyridine monohydrochloride (936342-91-5)

Guidance literature:

With thionyl chloride; at 20 ℃; for 12h;

Reference yield:

5-bromoisonicotinic acid (30766-11-1) → 5-bromo-2-chloromethylpyridine monohydrochloride (936342-91-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 12 h / 20 °C / Reflux

2: sodium tetrahydroborate / methanol / 12 h / 20 °C / Cooling with ice

3: thionyl chloride / 12 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sulfuric acid; In methanol;

Reference yield:

methyl 5-bromopicolinate (29682-15-3) → 5-bromo-2-chloromethylpyridine monohydrochloride (936342-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 12 h / 20 °C / Cooling with ice

2: thionyl chloride / 12 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In methanol;

upstream raw materials:

(5-bromopyridin-2-yl)methanol

5-bromoisonicotinic acid

methyl 5-bromopicolinate

Downstream raw materials:

5-bromo-2-(4-fluoro-phenoxymethyl)-pyridine

Refernces

• 1、 -. "PYRIDINE DERIVATIVES SUBSTITUTED BY HETEROCYCLIC RING AND PHOSPHONOAMINO GROUP, AND ANTI-FUNGAL AGENT CONTAINING SAME". Page/Page column 101. . Retrieved 2009/04/24.