6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

Base Information

Chemical Name:6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole
CAS No.:1067657-22-0
Molecular Formula:C₂₇H₂₀Cl₂N₄O
Molecular Weight:487.388
Hs Code.:

Synonyms:6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

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Chemical Property of 6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

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Technology Process of 6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

There total 4 articles about 6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067657-84-4
6-chloro-3-(1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl)-1H-indole-2-carboxylic acid

: 2576-47-8
2-bromoethylamine hydrobromide

: 1067657-22-0
6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

Guidance literature:: With triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; Heating / reflux;

Reference yield:

: 27034-51-1
ethyl 6-chloro-1H-indole-2-carboxylate

: 1067657-22-0
6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 28 h / 50 °C

2.1: triethylamine / ethanol / 3 h / 60 °C

3.1: sodium hydroxide; ethanol; water / 2.5 h / Heating / reflux

3.2: 0 °C

4.1: triethylamine; 1,1'-carbonyldiimidazole / tetrahydrofuran / Heating / reflux

With sodium hydroxide; ethanol; water; triethylamine; 1,1'-carbonyldiimidazole; trichlorophosphate; In tetrahydrofuran; ethanol;

Reference yield:

: 1067657-85-5
6-chloro-3-[3-(4-chlorobenzyl)-5-phenyl-3H-imidazol-4-yl]-1H-indole-2-carboxylic acid ethyl ester

: 1067657-22-0
6-chloro-3-[3-(4-chloro-benzyl)-5-phenyl-3H-imidazol-4-yl]-2-(4,5-dihydrooxazol-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol; water / 2.5 h / Heating / reflux

1.2: 0 °C

2.1: triethylamine; 1,1'-carbonyldiimidazole / tetrahydrofuran / Heating / reflux

With sodium hydroxide; ethanol; water; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran;