Technology Process of (3S,4R)-8-(3-(benzyloxy)phenyl)-3-methyloct-1-en-4-ol
There total 9 articles about (3S,4R)-8-(3-(benzyloxy)phenyl)-3-methyloct-1-en-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trans-2-Butene;
With
n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran; hexane;
at -40 ℃;
for 0.25h;
Inert atmosphere;
With
(-)-B-methoxydiisopinocamphenylborane;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
C18H20O2;
With
boron trifluoride diethyl etherate;
In
tetrachloromethane; hexane;
at -78 ℃;
for 2h;
optical yield given as %ee;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/jm300566h
- Guidance literature:
-
Multi-step reaction with 8 steps
1: thionyl chloride / methanol
2: potassium carbonate / acetone
3: lithium aluminium tetrahydride / tetrahydrofuran
4: triphenylphosphine; carbon tetrabromide / dichloromethane
5: sodium hydride / N,N-dimethyl-formamide
6: lithium chloride / dimethyl sulfoxide; water
7: diisobutylaluminium hydride / toluene
8: potassium tert-butylate; n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran
With
lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; carbon tetrabromide; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; lithium chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.tet.2014.11.026
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / toluene
2: potassium tert-butylate; n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran
With
n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
DOI:10.1016/j.tet.2014.11.026
