6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline

Base Information

• Chemical Name: 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline
• CAS No.: 1374108-00-5
• Molecular Formula: C₃₂H₃₅N₃O₇S
• Molecular Weight: 605.712
• Mol file: 1374108-00-5.mol

Synonyms:6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline

Chemical Property of 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline

There total 7 articles about 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3,4-dihydro-2H-pyran (110-87-2) + C27H27N3O6S (1374110-25-4) → 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline (1374108-00-5)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 78h;

Reference yield:

C33H41N3O6SSi (1374110-24-3) → 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline (1374108-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C

2: toluene-4-sulfonic acid / dichloromethane / 78 h / 20 °C

With toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

quinoline-2,6-diol (19315-93-6) → 6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline (1374108-00-5)

Guidance literature:

Multi-step reaction with 7 steps

1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

2: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

4: trifluoroacetic acid / chloroform / 0.5 h / 20 °C / Cooling with ice

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.33 h / 20 °C / Cooling with ice

6: trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C

7: toluene-4-sulfonic acid / dichloromethane / 78 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; water;

upstream raw materials:

C₃₃H₄₁N₃O₆SSi

3,4-dihydro-2H-pyran

C₂₇H₂₇N₃O₆S

quinoline-2,6-diol