1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline

Base Information

• Chemical Name: 1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline
• CAS No.: 122456-33-1
• Molecular Formula: C₁₉H₁₇ClN₂O₂
• Molecular Weight: 340.809

Synonyms:1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline

Chemical Property of 1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline

Chemical Property:

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Technology Process of 1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline

There total 2 articles about 1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-ethoxyethyl)-N,N'-bis(2-methoxyphenyl)malondiamide (122456-55-7) → 4-chloro-6-methoxy-2,3-dihydrofuro<3,2-c>quinoline (140633-18-7) + 1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline (122456-33-1)

Guidance literature:

With trichlorophosphate; Multistep reaction. Yields of byproduct given; 1.) diphenyl ether, reflux, 9 h, 2.) reflux, 2.5 h;

DOI:10.1021/jm00088a021

Reference yield:

diethyl 2-ethoxyethylmalonate (13487-89-3) → 1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline (122456-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 36.6 g / 3 h / 200 °C

2: 2.) phosphoryl chloride / 1.) diphenyl ether, reflux, 9 h, 2.) reflux, 2.5 h

With trichlorophosphate;

DOI:10.1021/jm00088a021

Reference yield: 42.0%

1-(2-methoxyphenyl)-4-chloro-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline (122456-33-1) → 1-(2-methoxyphenyl)-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline hydrochloride (122456-34-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2.25h; under 3000.2 Torr;

DOI:10.1021/jm00088a021

upstream raw materials:

2-(2-ethoxyethyl)-N,N'-bis(2-methoxyphenyl)malondiamide

diethyl 2-ethoxyethylmalonate

Downstream raw materials:

1-(2-methoxyphenyl)-6-methoxy-2,3-dihydropyrrolo<3,2-c>quinoline hydrochloride

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