4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID

Base Information

• Chemical Name: 4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID
• CAS No.: 83590-77-6
• Molecular Formula: C10H12 O5
• Molecular Weight: 212.202
• Hs Code.: 29189090
• Mol file: 83590-77-6.mol

Synonyms:Aceticacid, [4-(hydroxymethyl)-3-methoxyphenoxy]- (9CI)

Chemical Property of 4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID

Chemical Property:

• Vapor Pressure: 2.59E-07mmHg at 25°C
• Melting Point: 95 °C (dec.)
• Boiling Point: 405.8 °C at 760 mmHg
• Flash Point: 162.5 °C
• PSA: 75.99000
• Density: 1.306 g/cm³
• LogP: 0.65090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxymethyl-3-methoxyphenoxyaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): XnN
• Hazard Codes: Xn,N,Xi
• Statements: 22-37/38-41-50-36/37/38
• Safety Statements: 26-39-60-61-36/37/39-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-HydroxyMethyl-3-Methoxyphenoxyacetic acid is a acid labile resin linkage agent for use in SPPS. Suitable for the preparation of peptide fragments having tBu-based side chain protective groups.

Technology Process of 4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID

There total 3 articles about 4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 2-(4-hydroxymethyl-3-methoxyphenoxy)acetate → 4-hydroxymethyl-3-methoxyphenoxyacetic acid (83590-77-6)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 4h; Solvent; Reflux;

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → 4-hydroxymethyl-3-methoxyphenoxyacetic acid (83590-77-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C / Cooling with ice

3: sodium tetrahydroborate; ethanol / 3 h / 20 °C / Cooling with ice

4: sodium hydroxide; water / ethanol / 4 h / Reflux

With sodium tetrahydroborate; ethanol; water; sodium hydride; potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-hydroxy-4-<(carboxymethyl)oxy>benzaldehyde ethyl ester (96089-43-9) → 4-hydroxymethyl-3-methoxyphenoxyacetic acid (83590-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C / Cooling with ice

2: sodium tetrahydroborate; ethanol / 3 h / 20 °C / Cooling with ice

3: sodium hydroxide; water / ethanol / 4 h / Reflux

With sodium tetrahydroborate; ethanol; water; sodium hydride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2,4-Dihydroxybenzaldehyde

2-hydroxy-4-<(carboxymethyl)oxy>benzaldehyde ethyl ester

Downstream raw materials:

4-hydroxymethyl-3-methoxyphenylacetyl-ODhbt

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