1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

Base Information

Chemical Name:1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane
CAS No.:148150-73-6
Molecular Formula:C₂₄H₂₇NO₆
Molecular Weight:425.481
Hs Code.:

1-<N-(9-fluorenylmethyloxycarbonyl)-(1S,2S)-1-amino-2-hydroxypropyl>-4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

Synonyms:1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

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Chemical Property of 1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

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Technology Process of 1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

There total 2 articles about 1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 148150-73-6
1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / 1,3-dicyclohexylcarbodiimide (DCC), 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 3 h

2: 76 percent / BF₃*Et₂O / CH₂Cl₂ / 8 h / Ambient temperature

3: oxalyl chloride, DMSO / CH₂Cl₂ / 0.17 h / -78 °C

4: CH₂Cl₂; diethyl ether / 0.12 h / -78 °C

5: 75 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.17 h / -78 °C

6: LiBH₄, CH₃OH / CH₂Cl₂ / 10 h / -78 °C

With methanol; dmap; lithium borohydride; oxalyl dichloride; boron trifluoride diethyl etherate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;

Reference yield:

: 148150-69-0
1-[N-(9-fluorenylmethyloxycarbonyl)-(1S)-1-amino-2-oxopropyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

: 148150-73-6
1--4-methyl-2,6,7-trioxabicyclo<2.2.2>octane

: 148150-71-4
1-[N-(9-fluorenylmethyloxycarbonyl)-(1S,2R)-1-amino-2-hydroxypropyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

Guidance literature:: With lithium borohydride; In methanol; dichloromethane; at -78 ℃; for 15h; Product distribution; stereoselectivity, other solvents, other temperatures, other times, other reducing agents;
DOI:10.1016/S0040-4039(00)79241-0