N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

Base Information

Chemical Name:N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide
CAS No.:1622173-11-8
Molecular Formula:C₃₃H₃₄N₆O₄
Molecular Weight:578.671
Hs Code.:

Synonyms:N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

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Chemical Property of N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

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Technology Process of N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

There total 7 articles about N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1622173-54-9
5-(indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 51163-27-0
3,4-dimethylphenylisocyanate

: 1622173-11-8
N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1622173-11-8
N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: dimethyl amine / 16 h / 110 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 2 h / 100 °C / Sealed tube; Inert atmosphere

5: sodium cyanoborohydride; trifluoroacetic acid / 1.33 h / 0 - 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; dimethyl amine; N,N-dimethyl-formamide;

Reference yield:

: 1622173-53-8
5-(1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 1622173-11-8
N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; trifluoroacetic acid / 1.33 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With sodium cyanoborohydride; triethylamine; trifluoroacetic acid; In dichloromethane;