allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

Base Information

Chemical Name:allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate
CAS No.:864962-06-1
Molecular Formula:C₃₃H₃₇N₅O₄
Molecular Weight:567.688
Hs Code.:

Synonyms:allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

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Chemical Property of allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

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Technology Process of allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

There total 7 articles about allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 851075-67-7
allyl-N-2-[(3-amino-4-(methylamino)benzoyl)amino]ethyl-N-(2-naphthylmethyl)carbamate

: 27699-51-0
1-cyclohexanecarbonyl isothiocyanate

: 864962-06-1
allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2005.01.033

Reference yield:

: 851075-39-3
(2-amino-ethyl)-naphthalen-2-ylmethyl-carbamic acid allyl ester

: 864962-06-1
allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 1.5 h / 20 °C

2: tetrahydrofuran / 1.5 h / 20 °C

3: 1.8 g / SnCl₂*2H₂O; HCl / ethanol / 16 h / 20 °C

4: 44 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; DIPEA / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.01.033

Reference yield:

: 207305-49-5
tert-butyl 2-[(naphthalene-2-ylmethyl)amino]ethyl-carbamate

: 864962-06-1
allyl-N-2-[(2-[(cyclohexanecarbonyl)amino]-1-methyl-1H-benzimidazol-5-ylcarbonyl)amino]ethyl-N-(2-naphthyl-methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / K₂CO₃ / H₂O; tetrahydrofuran / 2 h / 20 °C

2: 74 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

3: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 1.5 h / 20 °C

4: tetrahydrofuran / 1.5 h / 20 °C

5: 1.8 g / SnCl₂*2H₂O; HCl / ethanol / 16 h / 20 °C

6: 44 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; DIPEA / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.01.033