3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

Base Information

Chemical Name:3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide
CAS No.:1240517-26-3
Molecular Formula:C₂₁H₁₉ClN₄O₄S₂
Molecular Weight:490.991
Hs Code.:

Synonyms:3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

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Chemical Property of 3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

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Technology Process of 3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

There total 9 articles about 3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373162-51-6
C₂₇H₃₃ClN₄O₅S₂Si

: 1240517-26-3
3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 110 ℃; for 0.25h; Microwave irradiation; Sealed vessel;

Reference yield:

: 1373162-32-3
C₂₅H₂₀Cl₂N₄O₆S₄

: 1240517-26-3
3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

Guidance literature:: With water; sodium hydroxide; In methanol; at 50 ℃;
DOI:10.1016/j.bmcl.2012.02.104

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1240517-26-3
3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; triethylamine / dichloromethane

2: pyridine / dichloromethane

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: water; sodium carbonate / N,N-dimethyl-formamide / 85 °C

5: potassium carbonate / N,N-dimethyl-formamide

6: tetrabutyl ammonium fluoride / tetrahydrofuran

With pyridine; dmap; tetrabutyl ammonium fluoride; water; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.02.104