2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride

Base Information

Chemical Name:2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride
CAS No.:956037-14-2
Molecular Formula:C₂₅H₂₆FNO₃*ClH
Molecular Weight:443.946
Hs Code.:

Synonyms:2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride

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Chemical Property of 2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride

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Technology Process of 2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride

There total 1 articles about 2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956037-85-7
4-bromo-3-fluoro-4'-methylbenzophenone

: 956037-29-9
N-[2,2-dimethyl-5-[2-[4-(5,5-dimethyl[1,3,2]dioxaborinan-2-yl)phenyl]ethyl]-1,3-dioxane-5-yl]acetamide

: 956037-14-2
2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride

Guidance literature:: 4-bromo-3-fluoro-4'-methylbenzophenone; N-[2,2-dimethyl-5-[2-[4-(5,5-dimethyl[1,3,2]dioxaborinan-2-yl)phenyl]ethyl]-1,3-dioxane-5-yl]acetamide; With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 6h; Heating / reflux;

With hydrogenchloride; In ethanol; water; at 70 ℃; for 3h;

Reference yield:

: 956037-14-2
2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 78-39-7
Triethyl orthoacetate

: 956037-83-5
C₃₅H₄₃FNO₆P

Guidance literature:: 2-amino-2-{2-[2'-fluoro-4'-(4-methylphenylcarbonyl)biphenyl-4-yl]ethyl}propane-1,3-diol hydrochloride; Triethyl orthoacetate; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

di-tert-butyl diisopropylphosphoramide; With 1H-tetrazole; In dichloromethane; at 0 - 20 ℃; for 2h;

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; more than 3 stages;