(S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

Base Information

Chemical Name:(S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid
CAS No.:1207954-33-3
Molecular Formula:C₂₄H₁₉F₃N₂O₃S
Molecular Weight:472.488
Hs Code.:

Synonyms:(S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

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Chemical Property of (S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

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Technology Process of (S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

There total 9 articles about (S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₁F₃N₂O₃S

: 1207954-33-3
(S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;

Reference yield:

: 1105187-36-7
3-bromo-4H-thiopheno[3,2-b]pyrrole-5-carboxylic acid methyl ester

: 1207954-33-3
(S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / 14 h / 20 °C

2: lithium hydroxide / methanol; tetrahydrofuran; water / 4 h / 55 °C

3: quinoline; copper / 4 h / 140 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / dimethyl sulfoxide / 24 h / 75 °C

5: lithium hydroxide / methanol; tetrahydrofuran; water / 5 h / 20 °C

6: 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 18 h / 20 °C

7: lithium hydroxide / methanol; tetrahydrofuran; water / 24 h / 20 °C

With 4-methyl-morpholine; quinoline; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper; caesium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 1207954-33-3
(S)-4-(1-{[4-(4-trifluoromethylbenzyl)-4H-thieno[3,2-b]pyrrole-3-carbonyl]-amino}-ethyl)-benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: sodium methylate / methanol / 2 h / -25 - 0 °C

2: 5,5-dimethyl-1,3-cyclohexadiene / 0.5 h / Reflux

3: caesium carbonate / 14 h / 20 °C

4: lithium hydroxide / methanol; tetrahydrofuran; water / 4 h / 55 °C

5: quinoline; copper / 4 h / 140 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / dimethyl sulfoxide / 24 h / 75 °C

7: lithium hydroxide / methanol; tetrahydrofuran; water / 5 h / 20 °C

8: 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 18 h / 20 °C

9: lithium hydroxide / methanol; tetrahydrofuran; water / 24 h / 20 °C

With 4-methyl-morpholine; quinoline; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium methylate; copper; caesium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; dimethyl sulfoxide; N,N-dimethyl-formamide;