(1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

Base Information

Chemical Name:(1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol
CAS No.:861220-01-1
Molecular Formula:C₁₆H₂₁BrO
Molecular Weight:309.246
Hs Code.:

Synonyms:(1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

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Chemical Property of (1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

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Technology Process of (1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

There total 1 articles about (1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10293-09-1
(1R,4R,7R)-9-bromocamphor

: 861220-01-1
(1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

Guidance literature:: PhMgX; With cerium(III) chloride; In tetrahydrofuran; at 0 ℃; for 1.5h;

(1R,4R,7R)-9-bromocamphor; In tetrahydrofuran;
DOI:10.1021/ol051141e

Reference yield:

: 861220-01-1
(1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

: 3-Bromo-1-((R)-4-methyl-3-phenyl-cyclohex-3-enyl)-propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / t-BuOK / dimethylsulfoxide / 70 °C

2: HBr

3: m-CPBA; NaHCO₃ / CH₂Cl₂ / 0 °C

4: 80 percent / ZnBr₂ / benzene / 0.17 h / 70 °C

With potassium tert-butylate; hydrogen bromide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; zinc dibromide; In dichloromethane; dimethyl sulfoxide; benzene; 4: Meinwald rearrangement;
DOI:10.1021/ol051141e

Reference yield:

: 861220-01-1
(1R,2S,4R,7R)-7-Bromomethyl-1,7-dimethyl-2-phenyl-bicyclo[2.2.1]heptan-2-ol

: (1S,4R)-3-(2-Bromo-ethyl)-2-methyl-1-phenyl-bicyclo[2.2.1]hept-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / t-BuOK / dimethylsulfoxide / 70 °C

2: HBr

With potassium tert-butylate; hydrogen bromide; In dimethyl sulfoxide;
DOI:10.1021/ol051141e