(4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

Base Information

Chemical Name:(4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid
CAS No.:168292-63-5
Molecular Formula:C₁₃H₁₄N₂O₅
Molecular Weight:278.265
Hs Code.:

Synonyms:(4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

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Chemical Property of (4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

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Technology Process of (4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

There total 1 articles about (4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 83056-78-4
tert-butyl (4S)-3-(benzyloxycarbonyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

: 168292-63-5
(4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 6h; Ambient temperature;
DOI:10.1021/jo00126a029

Reference yield:

: 168292-63-5
(4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

: (4S)-3-<(2S)-2-(N-Benzylamino)propionyl>-4-(tert-butoxymethyl)-1-methyl-2-oxoimidazolidine

Guidance literature:: Multi-step reaction with 5 steps

1: BMS / tetrahydrofuran / 1.) r.t., 2 h, 2.) reflux, 2 h

2: H₂SO₄ / CH₂Cl₂ / Ambient temperature

3: 93 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

4: 70 percent / t-BuOK / tetrahydrofuran / 1.) -50 deg C, 20 min, 2.) -30 deg C, 30 min

5: K₂CO₃ / hexamethylphosphoric acid triamide / 14 h / 25 °C

With dimethylsulfide borane complex; sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jo00126a029

Reference yield:

: 168292-63-5
(4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid

: 168292-68-0
(4S)-3-<(2R)-2-(N-Benzylamino)propionyl>-4-(tert-butoxymethyl)-1-methyl-2-oxoimidazolidine

Guidance literature:: Multi-step reaction with 5 steps

1: BMS / tetrahydrofuran / 1.) r.t., 2 h, 2.) reflux, 2 h

2: H₂SO₄ / CH₂Cl₂ / Ambient temperature

3: 93 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

4: 70 percent / t-BuOK / tetrahydrofuran / 1.) -50 deg C, 20 min, 2.) -30 deg C, 30 min

5: K₂CO₃ / hexamethylphosphoric acid triamide / 14 h / 25 °C

With dimethylsulfide borane complex; sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jo00126a029