2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

Base Information

Chemical Name:2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride
CAS No.:1243257-34-2
Molecular Formula:C₃₄H₃₇ClN₂O₆*ClH
Molecular Weight:641.592
Hs Code.:

Synonyms:2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

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Chemical Property of 2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

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Technology Process of 2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

There total 5 articles about 2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1243257-43-3
C₁₅H₂₃NO₃

: 20357-37-3
1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride

: 1243257-34-2
2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

Guidance literature:: C₁₅H₂₃NO₃; 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;

With hydrogenchloride; In diethyl ether;
DOI:10.1002/cjoc.201200196

Reference yield:

: C₁₅H₂₄BrNO₄

: 1243257-34-2
2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / 18 h / 180 °C

2: triethylamine / tetrahydrofuran / 6 h / 20 °C

With formic acid; triethylamine; In tetrahydrofuran; 1: Leuckart-Wallach reaction;
DOI:10.1002/cjoc.201200196

Reference yield:

: 4074-51-5
1-(4-isopropoxyphenyl)ethan-1-one

: 1243257-34-2
2-[2-(4-isopropoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide / ethanol / 6 h / Reflux

2: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C

3: formic acid / 18 h / 180 °C

4: triethylamine / tetrahydrofuran / 6 h / 20 °C

With formic acid; triethylamine; copper(ll) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; 3: Leuckart-Wallach reaction;
DOI:10.1002/cjoc.201200196