{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

Base Information

Chemical Name:{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester
CAS No.:260417-70-7
Molecular Formula:C₃₂H₄₁N₃O₆Si
Molecular Weight:591.78
Hs Code.:

{5-benzyloxy-2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

Synonyms:{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

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Chemical Property of {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

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Technology Process of {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

There total 1 articles about {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 260417-69-4
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 260417-70-7
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield:

: 260417-70-7
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: UP₂₀₇₄

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / AcOH / tetrahydrofuran; H₂O

2: 68 percent / (COCl)2; DMSO / CH₂Cl₂ / -45 °C

3: 100 percent / Pd(Ph₃)4; PPh₃; pyrrolidine / CH₂Cl₂

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; acetic acid; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 1: desilylation / 2: Cyclization / 3: Elimination;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield:

: 260417-70-7
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-cyanomethyl-2,3-dihydro-pyrrole-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 260417-72-9
8-benzyloxy-2-cyanomethyl-11-hydroxy-7-methoxy-5-oxo-11,11a-dihydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / AcOH / tetrahydrofuran; H₂O

2: 68 percent / (COCl)2; DMSO / CH₂Cl₂ / -45 °C

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; 1: desilylation / 2: Cyclization;
DOI:10.1016/S0960-894X(00)00351-6