TERT-BUTYL 3-(4-AMINOPHENYL)PROPANOATE

Base Information

• Chemical Name: TERT-BUTYL 3-(4-AMINOPHENYL)PROPANOATE
• CAS No.: 103790-48-3
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 103790-48-3.mol

Synonyms:1-tert-butyl 3-(4-aminophenyl)propionate

Chemical Property of TERT-BUTYL 3-(4-AMINOPHENYL)PROPANOATE

Chemical Property:

• Melting Point: 59-60 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 328.2±17.0 °C(Predicted)
• PKA: 4.73±0.10(Predicted)
• Density: 1.050±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

TERT-BUTYL-3-(4-AMINOPHENYL)PROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 3-(4-AMINOPHENYL)PROPANOATE

There total 3 articles about TERT-BUTYL 3-(4-AMINOPHENYL)PROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

t-butyl 3-(4-nitrophenyl)propanoate (103790-47-2) → 1-tert-butyl 3-(4-aminophenyl)propionate (103790-48-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; under 12001.2 Torr; Flow reactor;

DOI:10.1016/j.tet.2018.09.025

Reference yield: 80.0%

4-aminocinnamic acid tert-butyl ester (162936-33-6) → 1-tert-butyl 3-(4-aminophenyl)propionate (103790-48-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h; under 1810.02 Torr;

DOI:10.1021/jm00009a007

Reference yield:

3-(4-nitrophenyl)propionic acid (16642-79-8) → 1-tert-butyl 3-(4-aminophenyl)propionate (103790-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / toluene-p-sulphonic acid / pyridine / 17 h / Heating

2: 90 percent / hydrogen / Pd-C / dioxane

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; pyridine;

upstream raw materials:

t-butyl 3-(4-nitrophenyl)propanoate

4-aminocinnamic acid tert-butyl ester

3-(4-nitrophenyl)propionic acid

Refernces

• 1、 Cristalli, Gloria,Camaioni, Emidio,Vittori, Sauro,Volpini, Rosaria,Borea, Pier Andrea,et al.. "2-Aralkynyl and 2-Heteroalkynyl Derivatives of Adenosine-5'-N-ethyluronamide as Selective A2a Adenosine Receptor Agonists". . p. 1462 - 1472. Retrieved 2007/10/02.