Aliskiren inter-9

Base Information

Chemical Name:Aliskiren inter-9
CAS No.:866030-33-3
Molecular Formula:C28H46N2O5
Molecular Weight:490.684
Hs Code.:
Mol file:866030-33-3.mol

Synonyms:(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine;Aliskiren inter-9

Suppliers and Price of Aliskiren inter-9

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
500 mg
$ 315.00

Biosynth Carbosynth
(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
250 mg
$ 182.50

Biosynth Carbosynth
(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
100 mg
$ 91.00

Biosynth Carbosynth
(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
50 mg
$ 52.00

Biosynth Carbosynth
(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
1 g
$ 550.00

American Custom Chemicals Corporation
(2S,5R)-3,6-DIETHOXY-2,5-DIHYDRO-2-[(2S)-2-[[4-METHOXY-3-(3-METHOXYPROPOXY)PHENYL]METHYL]-3-METHYLBUTYL]-5-(1-METHYLETHYL)PYRAZINE 95.00%
5MG
$ 499.60

Total 11 raw suppliers

Chemical Property of Aliskiren inter-9

Chemical Property:

Refractive Index:1.511
Boiling Point:562.2 °C at 760 mmHg
Flash Point:234.2 °C
PSA：70.87000
Density:1.06 g/cm³
LogP:4.46330

Purity/Quality:

99% ^*data from raw suppliers

(2S,5R)-3,6-Diethoxy-2,5-dihydro-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Aliskiren inter-9

There total 10 articles about Aliskiren inter-9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 110117-71-0
(2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine

: 172900-69-5
(R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene

: 866030-33-3
(2R,5S)-3,6-diethoxy-2-isopropyl-5-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine

Guidance literature:: With n-butyllithium;
DOI:10.1016/j.tetlet.2005.07.028

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 866030-33-3
(2R,5S)-3,6-diethoxy-2-isopropyl-5-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / ethanol

2: PBr₃ / CH₂Cl₂

3: 76 percent / LiHMDS / tetrahydrofuran

4: 81 percent / LiOH; H₂O₂

5: 95 percent / LAH / tetrahydrofuran

6: 97 percent / PPh₃; NBS / CH₂Cl₂

7: 68 percent / n-BuLi

With lithium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; dihydrogen peroxide; phosphorus tribromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2005.07.028

Reference yield:

: 172900-71-9
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

: 866030-33-3
(2R,5S)-3,6-diethoxy-2-isopropyl-5-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / LAH / tetrahydrofuran

2: 97 percent / PPh₃; NBS / CH₂Cl₂

3: 68 percent / n-BuLi

With N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2005.07.028