(S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester
CAS No.:148797-38-0
Molecular Formula:C₂₃H₂₈N₃O₁₁P
Molecular Weight:553.463
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 15761-38-3
L-N-Boc-Ala

: 119552-95-3
di-p-nitrobenzyl 1-hydroxymethanephosphonate

: 148797-38-0
(S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

Guidance literature:: With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 148797-38-0
(S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

: 148797-50-6
(S)-2-Benzyloxycarbonylamino-4-{(S)-1-[bis-(4-nitro-benzyloxy)-phosphorylmethoxycarbonyl]-ethylcarbamoyl}-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.05 h / Ambient temperature

2: ethyl acetate; diethyl ether / 2 h / cooled

3: triethylamine / 1) methylene dichloride, -5 deg C, 30 min, 2) methylene dichloride, r.t., overnight

With triethylamine; In diethyl ether; ethyl acetate;

Reference yield:

: 148797-38-0
(S)-2-tert-Butoxycarbonylamino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

: (S)-2-Amino-propionic acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester; compound with oxalic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.05 h / Ambient temperature

2: ethyl acetate; diethyl ether / 2 h / cooled

In diethyl ether; ethyl acetate;