2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Base Information

Chemical Name:2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester
CAS No.:858346-76-6
Molecular Formula:C₄₄H₆₄O₁₀
Molecular Weight:752.986
Hs Code.:

2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Synonyms:2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

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Chemical Property of 2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

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Technology Process of 2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

There total 27 articles about 2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1312442-00-4
C₅₂H₇₂O₁₁

: 858346-76-6
2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 25 ℃; for 1h;
DOI:10.1021/ol201426c

Reference yield:

: 858346-74-4
2-{(2R,6S)-6-[(2R,4R,5S)-7-((2S,6R)-6-Allyl-tetrahydro-pyran-2-yl)-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid benzyl ester

: 858346-76-6
2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: tetrahydrofuran / 12 h / 20 °C

3: K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 24 h / 20 °C

4: 148 mg / HF*pyridine; pyridine / tetrahydrofuran / 1.5 h

With pyridine; potassium phosphate; pyridine hydrogenfluoride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki-Miyaura reaction;
DOI:10.1021/ol0510769

Reference yield:

: 858346-72-2
2-{(2R,6S)-6-[(2S,4R,5S)-4-Acetoxy-7-((2S,6R)-6-allyl-tetrahydro-pyran-2-yl)-2-hydroxy-5-methyl-heptyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid benzyl ester

: 858346-76-6
2-[(2R,6S)-6-((2R,4R,5S)-7-{(2S,6S)-6-[3-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-hydroxy-2-methoxymethoxy-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / iPr₂NEt / CH₂Cl₂ / 15 h / 20 - 50 °C

2: 70 percent / K₂CO₃; methanol / 60 h / 20 °C

3: 96 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: tetrahydrofuran / 12 h / 20 °C

5: K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 24 h / 20 °C

6: 148 mg / HF*pyridine; pyridine / tetrahydrofuran / 1.5 h

With pyridine; methanol; potassium phosphate; potassium carbonate; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 5: Suzuki-Miyaura reaction;
DOI:10.1021/ol0510769