1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea

Base Information

• Chemical Name: 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
• CAS No.: 611168-78-6
• Molecular Formula: C₃₀H₃₆N₆O₃
• Molecular Weight: 528.654

Synonyms:1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea

Chemical Property of 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea

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Technology Process of 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea

There total 3 articles about 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea → 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea (611168-78-6)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In ethanol; Heating;

DOI:10.1021/jm030121k

Reference yield:

3-(tert-butyl)-1-(4-nitrophenyl)-1H-pyrazol-5-amine (251658-55-6) → 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea (611168-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / tetrahydrofuran / 20 °C

2: DIPEA / dimethylsulfoxide / 20 °C

3: ammonium formate / Pd/C / ethanol / Heating

With pyridine; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm030121k

Reference yield:

[5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-yl]-carbamic acid phenyl ester → 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea (611168-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: DIPEA / dimethylsulfoxide / 20 °C

2: ammonium formate / Pd/C / ethanol / Heating

With ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm030121k

upstream raw materials:

3-(tert-butyl)-1-(4-nitrophenyl)-1H-pyrazol-5-amine

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