[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

Base Information

Chemical Name:[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate
CAS No.:287483-32-3
Molecular Formula:C₂₆H₃₇NO₄
Molecular Weight:427.584
Hs Code.:

Synonyms:[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

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Chemical Property of [1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

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Technology Process of [1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

There total 14 articles about [1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 287483-30-1
[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7aR]-7-(1',3'-benzodioxol-5'-yl)-2,3,3a,4,5,7a-hexahydro-1H-indole-1-carboxylate

: 287483-32-3
[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 18 ℃; for 16h;
DOI:10.1021/jo991791u

Reference yield:

: (1'α,5'α)-{6',6'-dibromobicyclo[3.1.0]hex-2'-ylidene}acetonitrile

: 287483-32-3
[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / PtO₂ / ethanol; CHCl₃ / 3 h / 18 °C / 2280.15 Torr

2: 430 mg / pyridine / CH₂Cl₂

3: 94 percent / silver acetate / 2,2,2-trifluoro-ethanol / 10 h / 18 °C

4: 49 percent / sodium carbonate; Pd(PPh₃)4 / benzene; ethanol; H₂O / 16 h / Heating

5: 100 percent / hydrogen / Pd/C / ethyl acetate / 16 h / 18 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; silver(I) acetate; sodium carbonate; platinum(IV) oxide; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; 2,2,2-trifluoroethanol; water; ethyl acetate; benzene; 1: Catalytic hydrogenation / 2: Acylation / 3: Ring cleavage / 4: Suzuki cross-coupling / 5: Catalytic hydrogenation;
DOI:10.1021/jo991791u

Reference yield:

: 2-((1R,2S,5S)-6,6-Dibromo-bicyclo[3.1.0]hex-2-yl)-ethylamine

: 287483-32-3
[1α(R*),2β,5α]-5-methyl-2-(1'-methylethyl)cyclohexyl-[3aS,7S,7aR]-7-(1',3'-benzodioxol-5'-yl)octahydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 430 mg / pyridine / CH₂Cl₂

2: 94 percent / silver acetate / 2,2,2-trifluoro-ethanol / 10 h / 18 °C

3: 49 percent / sodium carbonate; Pd(PPh₃)4 / benzene; ethanol; H₂O / 16 h / Heating

4: 100 percent / hydrogen / Pd/C / ethyl acetate / 16 h / 18 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; silver(I) acetate; sodium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate; benzene; 1: Acylation / 2: Ring cleavage / 3: Suzuki cross-coupling / 4: Catalytic hydrogenation;
DOI:10.1021/jo991791u