di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate

Base Information

• Chemical Name: di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate
• CAS No.: 1376377-37-5
• Molecular Formula: C₂₀H₂₂NO₉P
• Molecular Weight: 451.37
• Mol file: 1376377-37-5.mol

Synonyms:di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate

Chemical Property of di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate

There total 3 articles about di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

di(benzoyloxymethyl) 4-[benzyloxyamino]-4-oxobutylphosphonate (1376377-54-6) → di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate (1376377-37-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2012.02.031

Reference yield:

diethyl 4-(benzyloxyamino)-4-oxobutylphosphonate (1376377-42-2) → di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate (1376377-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 0.08 h

2.1: triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 20 - 70 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / 1 h / 20 °C

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.031

Reference yield:

chloromethyl benzoate (5335-05-7) + C11H16NO5P (1376377-44-4) → di(benzoyloxymethyl) 4-[hydroxyamino]-4-oxobutylphosphonate (1376377-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

1.2: 20 - 70 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.031

upstream raw materials:

chloromethyl benzoate

C₁₁H₁₆NO₅P

di(benzoyloxymethyl) 4-[benzyloxyamino]-4-oxobutylphosphonate

diethyl 4-(benzyloxyamino)-4-oxobutylphosphonate