(+/-)-EPIBATIDINE DIHYDROCHLORIDE

Base Information

Chemical Name:(+/-)-EPIBATIDINE DIHYDROCHLORIDE
CAS No.:162885-01-0
Molecular Formula:C₁₁H₁₃ClN₂*ClH
Molecular Weight:245.152
Hs Code.:
Mol file:162885-01-0.mol

Synonyms:7-Azabicyclo[2.2.1]heptane,2-(6-chloro-3-pyridinyl)-, dihydrochloride, exo- (9CI);7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, dihydrochloride, exo-(?à)-

Suppliers and Price of (+/-)-EPIBATIDINE DIHYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
EPIBATIDINE HYDROCHLORIDE 95.00%
5MG
$ 257.40

Total 6 raw suppliers

Chemical Property of (+/-)-EPIBATIDINE DIHYDROCHLORIDE

Chemical Property:

PSA：24.92000
LogP:4.27570
Solubility.:DMSO: >4 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

EPIBATIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s): A poison.
Hazard Codes:T+
Statements: 27/28
Safety Statements: 28-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Uses Agricultural chemical.

Technology Process of (+/-)-EPIBATIDINE DIHYDROCHLORIDE

There total 26 articles about (+/-)-EPIBATIDINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (1R,2R,4S)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: 152885-09-1,162885-01-0,166374-43-2
(+)-epibatidine hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1039/c39930001216

Reference yield: 100.0%

: (1R,2R,4S)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

: 152885-09-1,162885-01-0,166374-43-2
(-)-epibatidine hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1039/c39930001216

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 152885-09-1,162885-01-0,166374-43-2
(+)-epibatidine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) Et₂O, THF, -70 deg C

2: 1.) KH / 1.) THF, from 0 deg C to RT, 2.) THF, 0 deg C

3: toluene / 2 h / 110 °C

4: H₂ / PtO₂ / ethyl acetate / 2068.6 Torr

5: t-BuOK / 2-methyl-propan-2-ol / 30 h / 100 °C

7: 100 percent / HCl / ethyl acetate

With hydrogenchloride; n-butyllithium; potassium tert-butylate; hydrogen; potassium hydride; platinum(IV) oxide; In ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1039/c39930001216