N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

Base Information

Chemical Name:N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide
CAS No.:1365041-76-4
Molecular Formula:C₂₀H₂₂ClFN₄O₃S
Molecular Weight:452.937
Hs Code.:

Synonyms:N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

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Technology Process of N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

There total 4 articles about N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1365036-23-2
3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propan-1-amine

: 91170-93-3
4-fluoro-3-chlorobenzenesulfonyl chloride

: 1365041-76-4
N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

Guidance literature:: With triethylamine; In dichloromethane; at 10 - 20 ℃; for 3h;
DOI:10.1021/jm401895u

Reference yield: 60.0%

: 1365041-76-4
N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

Guidance literature:

Reference yield:

: 87691-89-2
4(1,2-benzisoxazol-3-yl)piperazine

: 1365041-76-4
N-[3-[4-(1,2-benzoxazol-3-yl)piperazin-1-yl]propyl]-3-chloro-4-fluorobenzene-sulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 20 °C

2: methylamine; water / 72 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 10 - 20 °C

With water; potassium carbonate; triethylamine; methylamine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401895u