3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine
• CAS No.: 1236354-94-1
• Molecular Formula: C₁₃H₇BrFN₇O
• Molecular Weight: 376.147

Synonyms:3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine

Chemical Property of 3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine

Chemical Property:

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Technology Process of 3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine

There total 1 articles about 3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-8-chloro-imidazo[1,2-a]pyrazine (143591-61-1) + 2-fluoro-4-(1H-tetrazol-1-yl)phenol (1037798-26-7) → 3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine (1236354-94-1)

Guidance literature:

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 6h;

Reference yield:

3-bromo-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine (1236354-94-1) + 5-ethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2H)-yl)pyrimidine (1236354-95-2) → 3-(1-(5-ethylpyrimidin-2-yl)-1,2,3,6-tetrahydropyridin-4-yl)-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine (1236354-93-0)

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

upstream raw materials:

3-bromo-8-chloro-imidazo[1,2-a]pyrazine

2-fluoro-4-(1H-tetrazol-1-yl)phenol

Downstream raw materials:

3-(1-(5-ethylpyrimidin-2-yl)-1,2,3,6-tetrahydropyridin-4-yl)-8-(2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)imidazo[1,2-a]pyrazine

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