2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

Base Information

Chemical Name:2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
CAS No.:1360788-51-7
Molecular Formula:C₁₆H₁₆N₂O₄
Molecular Weight:300.314
Hs Code.:

Synonyms:2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

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Chemical Property of 2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

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Technology Process of 2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

There total 1 articles about 2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 96562-96-8
2-bromoaldisine

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1360788-51-7
2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 95 ℃; for 18h;
DOI:10.1016/j.bmc.2011.12.054

Reference yield: 60.0%

: 1360788-51-7
2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

: 90567-37-6
2-(methylthio)-1,5-dihydro-4H-imidazol-4-one

: (Z)-2-(3,4-dimethoxyphenyl)-4-(2-(methylthio)-4-oxo-1H-imidazol-5(4H)-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Guidance literature:: 2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione; 2-(methylthio)-1,5-dihydro-4H-imidazol-4-one; With titanium tetrachloride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.5h;

With pyridine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 14.25h;
DOI:10.1016/j.bmc.2011.12.054

Reference yield:

: 1360788-51-7
2-(3,4-dimethoxyphenyl)-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

: (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 0.5 h / 0 °C

1.2: 14.25 h / 0 - 20 °C

2.1: ammonium hydroxide / tetrahydrofuran / 24 h / 90 °C / Sealed tube

With ammonium hydroxide; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.12.054