Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione,1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-7-methyl-3-phenyl-5-(1-pyrrolidinylcarbonyl)-

Base Information

Chemical Name:Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione,1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-7-methyl-3-phenyl-5-(1-pyrrolidinylcarbonyl)-
CAS No.:272774-82-0
Molecular Formula:C₃₄H₄₀N₆O₄
Molecular Weight:596.729
Hs Code.:

Synonyms:Pyrrolidine,1-[[1,2,3,4-tetrahydro-1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-7-methyl-2,4-dioxo-3-phenylpyrido[2,3-d]pyrimidin-5-yl]carbonyl]-(9CI)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione,1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-7-methyl-3-phenyl-5-(1-pyrrolidinylcarbonyl)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s): A poison.
Hazard Codes: A poison.:;
Safety Statements:A poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.:;"> x." target="_blank">A poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.:;

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Technology Process of Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione,1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-7-methyl-3-phenyl-5-(1-pyrrolidinylcarbonyl)-

There total 2 articles about Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione,1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-7-methyl-3-phenyl-5-(1-pyrrolidinylcarbonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 272774-71-7
1-(4-bromo-butyl)-7-methyl-3-phenyl-5-(pyrrolidine-1-carbonyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione

: 272774-82-0
1-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-7-methyl-3-phenyl-5-(pyrrolidine-1-carbonyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione

Guidance literature:: With potassium carbonate; In acetonitrile; for 12h; Heating;
DOI:10.1016/S0014-827X(99)00099-3

Reference yield:

: 259110-72-0
7-methyl-3-phenyl-5-(pyrrolidine-1-carbonyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione

: 272774-82-0
1-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-7-methyl-3-phenyl-5-(pyrrolidine-1-carbonyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: EtOK / ethanol

1.2: 60 percent / dimethylformamide / 20 °C

2.1: 60 percent / K₂CO₃ / acetonitrile / 12 h / Heating

With potassium ethoxide; potassium carbonate; In ethanol; acetonitrile; 1.1: Metallation / 1.2: Alkylation / 2.1: Alkylation;
DOI:10.1016/S0014-827X(99)00099-3