Ethanone,2-[3-[(4-bromophenyl)amino]-4,5-dihydro-2H-benz[g]indazol-2-yl]-1-(4-morpholinyl)-

Base Information

• Chemical Name: Ethanone,2-[3-[(4-bromophenyl)amino]-4,5-dihydro-2H-benz[g]indazol-2-yl]-1-(4-morpholinyl)-
• CAS No.: 301644-27-9
• Molecular Formula: C₂₃H₂₃BrN₄O₂
• Molecular Weight: 467.365
• Mol file: 301644-27-9.mol

Synonyms:Morpholine,4-[[3-[(4-bromophenyl)amino]-4,5-dihydro-2H-benz[g]indazol-2-yl]acetyl]- (9CI)

Chemical Property of Ethanone,2-[3-[(4-bromophenyl)amino]-4,5-dihydro-2H-benz[g]indazol-2-yl]-1-(4-morpholinyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): A poison by ingestion.
• Hazard Codes: A poison
• Safety Statements: A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx and Br−"> x and Br−." target="_blank">A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx and Br−

MSDS Files:

Useful:

Technology Process of Ethanone,2-[3-[(4-bromophenyl)amino]-4,5-dihydro-2H-benz[g]indazol-2-yl]-1-(4-morpholinyl)-

There total 3 articles about Ethanone,2-[3-[(4-bromophenyl)amino]-4,5-dihydro-2H-benz[g]indazol-2-yl]-1-(4-morpholinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

morpholine (110-91-8,99108-56-2) + [3-(4-bromo-phenylamino)-4,5-dihydro-benzo[g]indazol-2-yl]-acetic acid ethyl ester (301644-17-7) → 2-[3-(4-bromo-phenylamino)-4,5-dihydro-benzo[g]indazol-2-yl]-1-morpholin-4-yl-ethanone (301644-27-9)

Guidance literature:

at 100 ℃; for 4h;

DOI:10.1016/S0014-827X(00)00055-0

Reference yield:

1-tetralone-2-carbothionic acid p-bromo-anilide (125341-80-2) → 2-[3-(4-bromo-phenylamino)-4,5-dihydro-benzo[g]indazol-2-yl]-1-morpholin-4-yl-ethanone (301644-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: EtONa / ethanol / 0.08 h / 20 °C

1.2: 60 percent / CH₃COOH / 12 h / Heating

2.1: 65 percent / 4 h / 100 °C

With sodium ethanolate; In ethanol; 1.1: Metallation / 1.2: Condensation / 2.1: Acylation;

DOI:10.1016/S0014-827X(00)00055-0

Reference yield:

4-Bromophenyl isothiocyanate (1985-12-2) → 2-[3-(4-bromo-phenylamino)-4,5-dihydro-benzo[g]indazol-2-yl]-1-morpholin-4-yl-ethanone (301644-27-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 20 °C

1.2: 70 percent / dimethylformamide / 4 h / 20 °C

2.1: EtONa / ethanol / 0.08 h / 20 °C

2.2: 60 percent / CH₃COOH / 12 h / Heating

3.1: 65 percent / 4 h / 100 °C

With sodium ethanolate; sodium hydride; In ethanol; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Addition / 2.1: Metallation / 2.2: Condensation / 3.1: Acylation;

DOI:10.1016/S0014-827X(00)00055-0

upstream raw materials:

morpholine

[3-(4-bromo-phenylamino)-4,5-dihydro-benzo[g]indazol-2-yl]-acetic acid ethyl ester

1-tetralone-2-carbothionic acid p-bromo-anilide

4-Bromophenyl isothiocyanate

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